Protein name:
Ubiquitin thioesterase otulin ;
Alternative:
OTU domain-containing deubiquitinase with linear linkage specificity ;Deubiquitinating enzyme otulin ;Ubiquitin thioesterase Gumby ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with RNF31; the interaction is direct. Interacts with DVL2.
Function:
Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MSRGTMPQPG | AWPGASCAET | PAREAGAAAR | DGGKVTAGAQ | PRAATRCPAE |
100:
HEEDMYRAAD | EIEKEKELLI | HERGISEPRL | SVAPEMDIMD | YCKKEWRGNT |
150:
QKATCMKKGY | EEVSQKFTSI | RRVRGDNYCA | LRATLFQAMS | QLAELPPWLQ |
200:
DLELILLPEK | LINKYTWIKQ | WKLGLKFDGK | SEDLVEKIKE | SLALLRKKWV |
250:
SLAAMKTAEA | RQTACDELFT | NEEEEYSLYE | AVKFLMLNRA | IELYDDKEKG |
300:
KEVPFFSVLL | FARDTSNDPE | QLLRNHLNQV | GHTGGLEQVE | MFLLAYAVRH |
350:
SIRVYRLSKY | NTEEFITVYP | TDPPKDWPMV | TLIAEDDRHY | NIPVRVCEET |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Mouse
Human
Human
ELISA Kit for Mouse Ubiquitin thioesterase otulin
ELISA Kit for Mouse Ubiquitin thioesterase otulin
ELISA Kit for Mouse Ubiquitin thioesterase otulin
ELISA Kit for Mouse Ubiquitin thioesterase otulin
CLIA Kit for Mouse Ubiquitin thioesterase otulin
CLIA Kit for Mouse Ubiquitin thioesterase otulin
CLIA Kit for Mouse Ubiquitin thioesterase otulin
CLIA Kit for Mouse Ubiquitin thioesterase otulin
Polyclonal Antibody for Mouse Ubiquitin thioesterase otulin
Polyclonal Antibody for Mouse Ubiquitin thioesterase otulin
Polyclonal Antibody for Mouse Ubiquitin thioesterase otulin
Polyclonal Antibody for Mouse Ubiquitin thioesterase otulin
Monoclonal Antibody for Mouse Ubiquitin thioesterase otulin
Monoclonal Antibody for Mouse Ubiquitin thioesterase otulin
Monoclonal Antibody for Mouse Ubiquitin thioesterase otulin
Monoclonal Antibody for Mouse Ubiquitin thioesterase otulin
Protein for Mouse Ubiquitin thioesterase otulin
Protein for Mouse Ubiquitin thioesterase otulin
Protein for Mouse Ubiquitin thioesterase otulin
Protein for Mouse Ubiquitin thioesterase otulin
R&D Technical Data
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Precision
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Recovery
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Linearity
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Bone marrow .
tissue :
Olfactory bulb .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-352
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Mammary gland .
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Molar .
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PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;ACTIVE SITE;INTERACTION WITH RNF31 AND DVL2;MUTAGENESIS OF TRP-96; CYS-129; ASP-336 AND 349-GLU--VAL-352